Kathryn McMenimen,Jason E. Gestwicki,Brian DeVree,Leah Makley
申请号：
US16586479
公开号：
US20200140500A1
申请日:
2019.09.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides high throughput methods, protein inhibitors, and uses thereof. The invention provides high throughput methods of screening compounds for modulation of protein thermal stability, the method comprising contacting a protein with each of a plurality of test compounds； and (b) measuring the melting transition (Tm) of the protein in the presence of each of the plurality of test compounds, wherein a compound that decreases or increases the apparent Tm by at least 2 standard deviations is identified as a pharmacological protein chaperone.
