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Pharmaceutical compositions methods and kit for glucocorticoid replacement therapy
专利权人:
DUOCORT PHARMA AB
发明人:
SKRTIC, STANKO,JOHNSSON, JORGEN,LENNERNAS, HANS,HEDNER, THOMAS,JOHANNSSON, GUDMUNDUR
申请号:
NZ59848605
公开号:
NZ598486A
申请日:
2005.04.21
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
Disclosed is a coated tablet dosage form for delivery of glucocorticoid replacement therapy, comprising: an extended release (ER) tablet core and an immediate release (IR) coating surrounding said tablet core said ER core comprising hydrocortisone (HC) and an ER excipient composition composed of: a combination of hydroxypropylmethylcellulose, microcrystalline cellulose and pregelatinized starch colloidal silicon dioxide and magnesium stearate, the amount of HC present in said ER core being 60% to 80% of the total amount of HC present in said dosage form said IR coating material comprising HC and at least one coating material selected from the group consisting of methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, acrylic polymers, ethylcellulose, cellulose acetate phthalate, polyvinyl acetate phthalate, hydroxypropylmethylcellulose phthalate, polyvinylalcohol, sodium carobxymethylcellulose, cellulose acetate, gelatin, methacrylic acid copolymer, polyethylene glycol, shellac, sucrose, titanium dioxide, carnauba wax, microcrystalline wax, glyceryl monostearate, talc and zein, with the amount of HC present in said IR coating material being 20% to 40% of the total amount of HC present in said dosage form and said dosage form being effective to deliver a daily dose of from about 1 to 80 mg of HC.
来源网站:
中国工程科技知识中心
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