The invention provides methods for the identification of small molecules that inhibit MUC1 oligomerization, and the functions flowing therefrom. In addition, small molecules that prevent MUC1 oligomerization, such as some flavonoids, are disclosed. Identified molecules will find use in treating a variety of MUC1 -related inflammatory conditions, including MUC1 -related cancers. The screening methods involve two MUC1 -derived peptides comprising at least four consecutive residues of the MUC1 sequence and the motive CQC, e.g. CQCR, CQCRR, CQCRRR, CQCRRRR, CQCRRK and CQCRRKN.La présente invention concerne des procédés didentification de petites molécules inhibant loligomérisation de MUC1 et les fonctions qui en découlent. Linvention concerne, en outre, de petites molécules empêchant loligomérisation de MUC1. Les molécules identifiées peuvent être utilisées dans le cadre du traitement de diverses affections inflammatoires associées à MUC1, dont les cancers associés à MUC1.
