An ultrasonic microbubble target-locating controlled releasing drug/gene device and a method used for realizing target transfer of microbubble contrast agent combined with drug/gene by ultrasonic are disclosed. The ultrasonic microbubble target-locating controlled releasing drug/gene device comprises ultrasonic triggering/treating unit, monitoring unit, movement system connected with the ultrasonic triggering/treating unit and the monitoring unit, driving unit connected with the ultrasonic triggering/treating unit, computer control unit respectively connected with the movement system, the driving unit and the monitoring unit. The computer control unit comprises input system, computer center and output system.