A stable pharmaceutical composition is provided. The pharmaceutical composition comprises: (a) a medium system, comprising a first component, a second component and a third component, wherein the first component is a phosphate buffered saline, the second component is selected from the group consisting of vegetable oils, animal oils, fatty acids and combinations thereof, and the third component is selected from the group consisting of polyethylene glycol, dimethyl sulfoxide (DMSO), ethanol, propylene glycol, polysorbate, polyoxyethylated vegetable oil, ethyl acetate, 2- hydroxyethyl 12-hydroxyoctadecanoate, tocopheryl polyethylene glycol succinate and combinations thereof； and (b) n- butylidenephthalide (BP).一種穩定醫藥組合物，包含：(a)一介質系統，包含第一成分、第二成分、及第三成分，該第一成分係磷酸鹽緩衝液，該第二成分係選自以下群組：植物油、動物油、脂肪酸及其組合，且該第三成分係選自以下群組：聚乙二醇、二甲亞碸、乙醇、聚丙二醇、聚山梨醇酯、聚氧乙基化蔬菜油、乙酸乙酯、12-羥基硬酯酸羥乙酯、維生素E聚乙二醇琥珀酸酯、及其組合；以及(b)亞丁基苯酞(n-butylidenephthalide,BP)。
