Randall V. Sparer;Mark S. Lent;Kenneth T. Heruth;Christopher M. Hobot;Maura G. Donovan;William J. Hooper;Ruchika Singhal;Robert M. Skime;William J. Bertrand
发明人:
Kenneth T. Heruth,Christopher M. Hobot,William J. Hooper,Mark S. Lent,Ruchika Singhal,Robert M. Skime,Randall V. Sparer,Maura G. Donovan,William J. Bertrand
申请号：
US11008445
公开号：
US08691258B2
申请日:
2004.12.09
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
