ФЛОР Александр (DE),ГРЁБКЕ ЦБИНДЕН Катрин (CH),КЁРНЕР Маттиас (DE),ЛЕРНЕР Кристиан (CH)
申请号：
RU2014150494
公开号：
RU2014150494A
申请日:
2013.05.27
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The compound of formula (I) where A, A and A are independently N or C, provided that A, A and A are not N at the same time, B is CC-alkylene, CC-alkenylene, -OCC-alkyl or -NH-CC- alkyl R and R are independently selected from hydrogen, CC-alkyl, CC-hydroxyalkyl, CC-cycloalkyl, R and R, together with the nitrogen atom to which they are attached, form heterocycloalkyl, which may be substituted by 1-3 substituents independently selected from the group consisting of halogen, CC-alkyl, CC-hydroxyalkyl, CC-alkoxy, CC-haloalkyl, hydroxyl and oxo； R selected from heteroaryl, optionally substituted with 1 to 3 substituents selected from halogen, CC-alkyl, cycloalkyl, CC-alkoxy, CC-haloalkyl, aryl, heteroaryl, -NRR, -OR, -C (O) -NR′R ″, where heteroaryl contains at least one nitrogen atom that is adjacent to the bonding carbon atom, R is selected from hydrogen, CC-alkyl, CC-cycloalkyl, R and R are independently selected from hydrogen, CC-alkyl, R and R, together with the nitrogen atom to which they are attached, form heterocycloalkyl, which may be substituted by 1-3 substituents independently selected from the group consisting of halogen, CC-alkyl, CC-hydr hydroxyalkyl, C-C-alkoxy, C-C-haloalkyl and oxo； R is selected from C-C-alkyl, C-C-haloalkyl and heterocycloalkyl, R ′ and R ″ are independently selected from hydrogen and C-C-alkyl. 2. A compound according to claim 1, wherein A and A and A are C.3. The compound of claim 1, wherein A is N and A is C.4. The compound of claim 1, wherein C is A and A is N.5. A compound according to claim 1, wherein B is C-C-alkylene, C-C-alkenylene, -O-C-alkyl, -NH-C-alkyl, preferably ethylene, ethenylene, -O-C-alkyl. The compound of claim 1, wherein R and R, together with the nitrogen atom to which they are attached, form a 4-6 membered heterocycloalkyl containing one or two heteroatoms selected from N and O, preferably selected from the group consisting1. Соединение формулы (I)гдеA, Aи Aнезависимо представляют собой N или C, при условии, ч
