method of producing a compound, and, compound农业专利-农业学术服务平台

摘要：: 1/1 Summary "Method of Producing a Compound, and Compound" The present invention addresses the problem of providing an efficient process for preparing intermediate compounds (1) and ( 1a) important for the production of fxa (x) and (xa) inhibitors. The present invention relates to: a process which is useful for preparing a compound represented by the formula (8d) and which includes stereoselective intramolecular cyclization； and a process which is useful for preparing a compound (1f), a salt thereof or a hydrate of any one and which is characterized in that it includes desulphonylation of a compound (8d). in each formula, r is alkyl c, benzyl or the like. 1-6 (8d) (1f)1 / 1 resumo â€œmã‰todo de produã‡ãƒo de um composto, e, compostoâ€� a presente invenã§ã£o dedica-se ao problema de fornecer um processo eficiente para preparar compostos intermediã¡rios (1) e (1a) importantes para a produã§ã£o de inibidores de fxa (x) e (x-a). a presente invenã§ã£o refere-se a: um processo que ã© ãºtil para preparar um composto representado pela fã³rmula (8d) e que inclui ciclizaã§ã£o intramolecular estereosseletiva； e um processo que ã© ãºtil para preparar um composto (1f), um sal do mesmo ou um hidrato de qualquer um e que ã© caracterizado pelo fato 4a de incluir a dessulfonilaã§ã£o de um composto (8d). em cada fã³rmula, r ã© alquila c , benzila ou semelhantes. 1-6 ( 8d ) ( 1f )