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INHIBITEURS DE LA TRYPTOPHANE-2,3-DIOXYGÉNASE OU DE L'INDOLEAMINE-2,3-DIOXYGÉNASE
专利权人:
IOMET PHARMA LTD
发明人:
COWLEY, Phillip,WISE, Alan
申请号:
EPEP2015/075471
公开号:
WO2016/071283A1
申请日:
2015.11.02
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Provided is a compound for use in medicine for inhibiting tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO), which compound comprises formula (I) wherein X1, X2, and X7, may be the same or different and each is independently selected from C and N; X3, X4, X5, and X6 may be the same or different and each is independently selected from C, N, O and S wherein when X3 is N it has a double bond and wherein when X6 is N it has a double bond; the dotted line is a bond which may be present or absent; R1, R2, R3, R4, R5, R6, and R7 may be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that at least one of R2, R3, R4 and R6 comprises a group Y; and provided that the number of R1, R2, R3, R4, R5, R6, and R7 groups present is such that the respective valencies of X1, X2, X3, X4, X5, X6, and X7 are maintained; and wherein Y is a group having a formula selected from (II), (III), (IV), (V) wherein L may be present or absent, and may be a substituted or unsubstituted organic linking group, and R31 and R32 may be the same or different and are selected from H and a substituted or unsubstituted organic group, X8 is selected from C and N, and each R313 may be the same or different and is selected from H and a substituted or unsubstituted organic group.L'invention concerne un composé destiné à être utilisé en médecine pour inhiber la tryptophane-2,3-dioxygénase (TDO) et/ou l'indoleamine-2,3-dioxygénase (IDO), lequel composé répond à la formule suivante (I) : dans laquelle X1, X2 et X7 peuvent être identiques ou différents et chacun est indépendamment choisi parmi C et N; X3, X4, X5 et X6 peuvent être identiques ou différents et chacun est indépendamment choisi parmi C, N, O et S, X3 contenant une double liaison lorsqu'il correspond à N et X6 contenant une double liaison lorsqu'il correspond à N; la ligne en pointillés est une liaison qui peut être présente ou a
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