OBRECHT, DANIEL,LUTHER, ANATOL,BERNARDINI, FRANCESCA,ZBINDEN, PETER
申请号：
CA2908388
公开号：
CA2908388A1
申请日:
2014.03.28
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Beta-hairpin peptidomimetics of the general formula (I), cyclo(P1-p2-p3-p4-p5-p6- p7p8p9-p10-p11-p12-T1-T2], a nd pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have broad spectrum Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
