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Compositions and Methods for Treating and Diagnosing Cancer
专利权人:
OncoMed Pharmaceuticals; Inc.
发明人:
AUSTIN GURNEY
申请号:
US13801198
公开号:
US20130336970A1
申请日:
2013.03.13
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cells. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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