MARQUARDT TOBIAS,BOTHE ULRICH,BARAK NAOMI,BUSEMANN MATTHIAS,FISCHER OLIVER MARTIN,ROTGERI ANDREA,GASHAW ISABELLA,HARTUNG INGO
申请号：
NZ62208112
公开号：
NZ622081A
申请日:
2012.09.24
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein are estra-1,3,5(10),16-tetraene-3-carboxamide derivatives of formula I where the substituents are as defined herein. The compounds are AKR1C3 inhibitors and are intended for the use for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding problems and endometriosis. Specific examples of the compounds of formula I include 4-[({ [17-(5-fluoropyridin-3-yl)estra-1,3,5(10),16-tetraen-3-yl]carbonyl} amino)methyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxylic acid and N-methyl-N-{ [17-(3-pyridin-3-yl)estra-1,3,5(10),16-tetraen-3-yl]carbonyl} -B-alanine.
