Pascale Feldmann,Jeffrey David Fowler,Wendy Maddelein,Nina Cromheecke,Isabelle Maillet
申请号：
US15765941
公开号：
US20180289015A1
申请日:
2016.09.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a method of substantially retaining or otherwise preserving the biological activity of a dsRNA, present in a cell lysate, to post-transcriptionally silence the expression of a gene in a target organism, comprising the step of adding to the lysate a compound having the function of a protein- or amine-cross linking agent. The invention also comprises compositions comprising the lysate comprising dsRNA, and protein cross linking agents, as well as the use of said agents in the method.
