The invention relates to a method of determining the sympathetic tone Including thesteps of: measuring an applied stimulation at a threshold value of the stimulation inone or more sympathetic tone-neutral points and measuring an applied stimulation atthe same threshold value in one or more sympathetic tone-dependent points. Theinvention further relates to a system for applying and measuring a stimulation, andthe use of a system for applying and measuring a stimulation for determining thesympathetic tone including the steps of: measuring an applied stimulation ata threshold value of the stimulation at one or more sympathetic tone-neutral pointsand measuring an applied stimulation at the same threshold value of the stimulationat one or more sympathetic tone-dependent points.