Sa-Won Lee,Joong-Woong Cho,Gyeong-Hae Kim,Min-Hyo Seo
申请号：
US14362234
公开号：
US20140335194A1
申请日:
2012.12.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are a polymeric drug carrier-containing pharmaceutical composition with enhanced stability in its solution state and a method for stabilizing the same. More particularly, disclosed are a pharmaceutical aqueous solution composition for storage under refrigeration containing a polymeric drug carrier comprising an amphiphilic block copolymer comprised of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative fixed with a di- or tri-valent metal ion at its terminal carboxyl group and having preservation stability for at least 6 months, preferably at least 12 months when stored under refrigeration, and a method for stabilizing the same.
