The invention relates to the methods for soil cultivation, in particular under desert and semi-desert conditions, which enables to increase productivity while saving the soil fertility. It is proposed to form, in pre-sowing period, a screening layer mixed with the soil at the depth of the topsoil and containing milled sodium bentonite and a poultry manure previously treated with an enzyme preparation produced under name of Oxyzyme. After sowing or planting the plants, the screening layer is saturated with water, into the water of the first watering another enzyme preparation - Agrozyme, being added in a certain ratio with water. Optimum conditions of carrying out of the method allow to ensure effective development of biocoenosis and, as a result, to achieve restoration and increase of the fertility of the cultured soil.