YUNBAIYAO ZHENGWU SCIENCE AND TECHNOLOGY (SHANGHAI) CO.; LTD.
发明人:
Jinghua Zhang,Zhengwu Shen
申请号：
US16657908
公开号：
US20200046679A1
申请日:
2019.10.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described is a dihydroartemisinin-steroid conjugate of formula (I), or a pharmaceutically acceptable salt thereof, where position 10 of dihydroartemisinin is linked to the steroid through a linker X. This application further provides a preparation method of the dihydroartemisinin-steroid conjugate and an application of the dihydroartemisinin-steroid conjugate in the preparation of a drug for treating cancer. The dihydroartemisinin-steroid conjugate of the invention exhibits potent inhibitory activity against various tumor cells and low cytotoxicity, moreover, the conjugate is capable of penetrating the blood-brain barrier, having a broad application prospect.
