#$%^&*AU2016203988B220180125.pdf#####Abstract: The present application is directed to methods of promoting angiogenesis, including vascularizing an avascular site, or extending or enhancing existing vasculature comprising contacting tissue with a protein substantially similar to pyruvate kinase M2. The present application is also directed to proteins comprising pyruvate kinase M2 and pharmaceutical compositions comprising pyruvate kinase M2.