Biosafety blade devices that aid in the manipulation and safety of either single-edged or double-edged razor blades are disclosed. The devices include finger guards that assist with holding and manipulating a razor blade. The device also includes various embodiments of blade guards that prevent accidental contact with the sharp edge of a razor blade, securely lock a blade preventing reuse, minimize recoil and flying projectiles, control the depth of a skin biopsy, reversibly fix blade curvature and allow for tissue to be measured and securely held to the blade or easily expelled into a specimen container. The components of the biosafety blade, i.e., the finger guards and blade guards, can be used separately or they can be combined to provide for maximum comfort, accuracy, versatility and safety.
