LIU, FANG,AMPHLETT, GODFREY W.,MESHULAM, DEBORAH H.
申请号：
EP12856692
公开号：
EP2790724A4
申请日:
2012.12.13
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved stability in the presence of exogenous NHS. In some embodiments, the inventive process comprises the addition of a molar ratio of exogenous NHS with respect to the amount of NHS generated during the modification reaction as a result of hydrolysis/aminolysis of the bifunctional linker.
