The preparation of a kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution containing ginsenoside Rg3 0.5ˆ¼10 mg/ml: add 0.1-5% of ginsenoside solution to 0.1ˆ¼30% of adjuvant A, B‘ ‘¡‘¤ at the temperature of 40ˆ¼100°C, the ratio of these two is 1:1ˆ¼300, add water after the solvent is recycled under reduced pressure; another kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution contains 0.1ˆ¼2mg/ml of 20 (R) of the ginsenoside Rg3, the preparation: add 0.1ˆ¼5% of ginsenoside solution to 20ˆ¼65% of adjuvant B‘¢‘£ at the temperature of 60ˆ¼100°C, main material to adjuvant B=1:100ˆ¼400, add water after the solvent is recycled under reduced pressure. The above 20 (R) ginsenoside Rg3 composition aqueous solution and the powder after lyophilizaton can be used to prepare injectable, oral administration and external use, and the bioactivity of these preparations is high, and with the actions of anti cancer, efficacy potentiation and toxicity attenuation effects of the combined chemical or radiation therapy of tumor, enhancement of human immune functions, improvement of human memory, anti fatigue, and detumescence, pain relieving.