A high-speed rotational atherectomy device for opening a stenosis in an artery having a given diameter, comprising: a guide wire a flexible elongated, rotatable drive shaft advanceable over the guide wire, the drive shaft having a proximal end and a distal end an abrading head and a piloting member fixedly attached to the drive shaft and disposed distally of the abrading head. When the piloting member is advanced to a stenosis, the piloting member creates a piloting hole when the drive shaft at a sufficient rotational speed. The eccentric abrading head is then advanced through the piloting hole and distally across the stenotic lesion, thereby opening the stenotic lesion to a diameter larger than the nominal diameter of the eccentric enlarged diameter section.
