The invention discloses means of utilizing Noble Gases for inhibition of pathogenic processes associated with Alzheimers Disease progression, as well as reversal of Alzheimers Disease. In one embodiment compositions containing xenon gas are administered alone or together with therapeutic interventions for treatment of Alzheimers Disease. In another embodiment, taupathies such as chronic traumatic encephalopathy are treated by administration of xenon or Noble Gas containing mixtures.