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NOVEL ANTIBODIES INHIBITING C-MET DIMERIZATION, AND USES THEREOF
专利权人:
发明人:
GOETSCH LILIANE
申请号:
IN201718033959
公开号:
IN201718033959A
申请日:
2017.09.25
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
An isolated antibody, or one of its functional divalent fragments capable of binding to the c-Met, characterized in that said isolated antibody or said functional divalent fragments is selected from: a) an antibody comprising a heavy chain comprising CDR-HI, CDR- HZ and CDR-H3 comprising respectively the amino acid sequence SEQ ID Nos. 56, 57 and 58 and a light chain comprising CDR-L1, CDR-L2 and CDR-L3 comprising respectively the amino acid sequence SEQ ID Nos. 59, 60 and 61 b) an antibody comprising a heavy chain comprising CDR-HI, CDR-H2 and CDR-H3 comprising respectively the amino acid sequence SEQ ID Nos. 4, 5 and 6 and a light chain comprising CDR-L1, CDR-L2 and CDR-L3 comprising respectively the amino acid sequence SEQ ID Nos. 13, 11 and 14 and c) an antibody comprising a heavy chain comprising CDR-HI, CDR-H2 and CDR-H3 comprising respectively the amino acid sequence SEQ ID Nos. 7, 8 and 9 and a light chain comprising CDR-L1, CDR-L2 and CDR-L3 comprising respectively the amino acid sequence SEQID Nos. 15, 16 and 17.
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