MA, Cunbo,GAO, Panliang,HU, Shaojing,XU, Zilong,HAN, Huifeng,WU, Xinping,KANG, Di
申请号：
CL2019002698
公开号：
CL2019002698A1
申请日:
2019.09.23
申请国别(地区):
CL
年份:
2020
代理人:
摘要：
According to F amp, oacute, rmula I, Su s amp, Iacute, ntesis and their use in the treatment of SHP2 moderate disorder, n is a pyridydan derivative as an inhibitor of SHP2. M amp； Aacute； s, especially the current invention and amp； oacute； n refer to heterogenous and amperometric derivatives； Iacute； combined cells； uacut； tiles； eacute as SHP2, M amp； amp； eacute； all tiles for the production of these compounds； and M amp； eacute； all for the treatment of disorders caused by SHP2. lt； P gt；<；p>；La presente invenció；n se refiere a derivados de pirazina como inhibidores de SHP2 de acuerdo con la fó；rmula I, su sí；ntesis y su uso para tratar un trastorno mediado por SHP2. Má；s particularmente, la presente invenció；n se refiere a derivados de grupos heterocí；clicos fusionados, ú；tiles como inhibidores de SHP2, mé；todos para producir tales compuestos y mé；todos para tratar un trastorno mediado por SHP2.<；/p>；
