as represented by the Secretary Department of Health and Human Services;Government of the United States of America
发明人:
Keefer, Larry K.,Hrabie, Joseph A.,DeRosa, Frank
申请号：
AU2011200972
公开号：
AU2011200972C1
申请日:
2011.03.04
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011200972C120120524.pdf#####ABSTRACT The invention described herein provides for novel nitric oxide-releasing polymers that comprise at least two adjacent units derived from acrylonitrile monomer units and containing at least one carbon-bound diazeniumdiolate. The diazeniumdiolated acrylonitrile-derived polymers can be used in medical devices therapeutically. Accordingly, the invention also provides a method of treating a biological disorder and a method of promoting angiogenesis that includes administering a medical device comprising a nitric oxide-releasing polymer comprising at least two adjacent units of acrylonitrile before exposure to nitric oxide and at least one nitric oxide releasing N20 2- group, wherein the N20 2- group is attached directly to the polyacrylonitrile backbone, to a specific location on or within the mammal in an amount effective to treat the biological disorder or promote angiogenesis.1/8 Figure la 6.00E-10 5.OOE-10 E 4.OOE-10 3.00E-10 C E 2.00E-10 0 1.00E-10 0.00E+00 0.00 5.00 10.00 15.00 20.00 25.00 30.00 Time (min) Figure lb 8.OOE-11 7.OOE-11 E 6.00E-11 E5.00E-1 1 0 Z 4.00E-11 a) 0 3.00E-11 E 2.OOE-11 1.00E-11 0.00E+00 0.00 50.00 100.00 150.00 200.00 250.00 300.00 Time (min)
