Bernard Barlaam,Christopher De Savi,Janet Hawkins,Alexander Hird,Michelle Lamb,Kurt Pike,Melissa Vasbinder
申请号：
US15833277
公开号：
US10717746B2
申请日:
2017.12.06
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are a series of novel pyridine or pyrimidine derivatives which inhibit CDK9 and may be useful for the treatment of hyperproliferative diseases. In particular the compounds are of use in the treatment of proliferative disease such as cancer including hematological malignancies such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt's lymphoma, follicular lymphoma and solid tumors such as breast cancer, lung cancer, neuroblastoma and colon cancer.
