The invention relates to dihydroorate dehydrogenase (DHODH) inhibitors useful for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis.Linvention concerne des inhibiteurs de dihydroorate déshydrogénase (DHODH) utiles pour le traitement de maladies neurodégénératives, telles que la sclérose latérale amyotrophique.