Provided are a novel chlorin e6 derivative and pharmaceutically-acceptable salts thereof, a preparation method therefor, and an application thereof, relating to the technical field of pharmacy. The chlorin e6 derivative ether-based amino acid derivative comprises structural general formula I and an optical isomer of the structural general formula I. The preparation method is: etherifying 3-vinyl in chlorin e6, and producing peptide from 15-acetate carboxyl and amino acid. The chlorin e6 derivative ether-based amino acid derivative and pharmaceutically-acceptable salts thereof can be used as anti-tumor drugs of photodynamic therapy. As compared with Talaporfin which is the existing clinically-used photosensitizer, the novel chlorin e6 derivative has advantages of stronger anti-tumor activity and higher dark toxicity-phototoxicity ratio, and can be used for preparing novel anti-tumor drugs of the photodynamic therapy, including caner-treating drugs of photodynamic therapy, drugs for treating benign vascular diseases by the photodynamic therapy such as macular degeneration and nevus flammeus, as well as drugs for treating condyloma acuminate by the photodynamic therapy.La presente solicitud se refiere a nuevos derivados de la clorina e6 y sus sales farmacéuticas aceptables, así como a su preparación y uso dentro del campo de la medicina. El derivado de clorina e6 éter aminoácido consta de la fórmula estructural general I y de sus isómeros ópticos (ver Fórmula). El proceso de preparación consiste en la eterificación del 3-vinilo en la clorina e6, produciéndose un péptido a partir del 15-carboxiletilo y aminoácido. El derivado de clorina e6 éter aminoácido y su sal farmacéuticamente aceptable pueden utilizarse como medicamento antitumoral fotodinámico. Si se compara el resultado con un fotosensibilizador similar al anterior utilizado clínicamente, como el Talaporfín, el derivado de clorina e6 éter aminoácido de la solicitud actual posee actividades antitumorales fotodiná
