Production of 6-hydroxy morphinans without the isolation of intermediates

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专利权人:

Mallinckrodt LLC

发明人:

Wang, Peter X.,Jiang, Tao

申请号：

AU2014346883

公开号：

AU2014346883A1

申请日:

2014.11.05

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The present invention provides a process for preparing a saturated 6,14-dihydroxy morphinan. The process comprises contacting an unsaturated 6-O-hydrocarbyl morphinan with hydrogen peroxide and an organic acid to form an unsaturated 6-keto-14-hydroxy morphinan. The unsaturated 6-keto-14-hydroxy morphinan is contacted with a first reducing agent to form an unsaturated 6,14-dihydroxy morphinan, and the unsaturated 6,14-dihydroxy morphinan is contacted with a second reducing agent to form the saturated 6,14-dihydroxy morphinan.

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