A powder composition comprising calcium acetate monohydrate, aluminum sulfate tetradecahydrate and a third component selected from potassium permanganate (KMnO4) and chloramine-T (sodium N-chloro-4-toluenesulfonamidate), and a pharmaceutical formulation for topical application comprising the aforementioned components and a pharmaceutically acceptable carrier are described a pharmaceutical formulation comprising basic aluminum acetate and a component selected from potassium permanganate and chloramine-T is also described such pharmaceutical formulations are intended for use in the topical treatment of skin conditions such as swelling, hives, eczemas, erythemas, insect bites, bruises, itching, vesicular or bullous exudation, crusted lesions, skin ulcers, atopic dermatitis, herpes zoster, herpes simplex, intertrigo and sunburn.