您的位置: 首页 > 农业专利 > 详情页

Heteroaryl compounds as inhibitors of BTK and Uses Thereof
专利权人:
MERCK PATENT GMBH
发明人:
申请号:
ARP150103209
公开号:
AR102177A1
申请日:
2015.10.06
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
1. Pyridane compounds as Btk inhibitors and the components that can be accepted in medicine; 1. Claim 1: a formula compound (1),a. Ring a is arilo, or 5 to 6 members of pagan; R1 is h, halo, (C (r830909) (r8344nr2);N (R) C (O) R N (R) C (O) NRN (R⁴) CO₂R, N (R⁴) S (O) ₂R, N (R⁴) S (O) R, N (R⁴) (R⁴),optionally substituted 3 to 7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or optionally substituted 5 to 6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; or R¹ is absent; R² is H, (C (R⁵) (R⁵)) ₘOR⁴,(C (R⁵) (R⁵)) ₘN (R⁴) COR, (C (R⁵) (R⁵)) ₘN (R⁴) C (O) C (O) NR₂,(C (R) (R)) N (R) (R)optionally substituted 3 to 7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or optionally substituted 5 to 6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; or R² is absent; or R¹ and R² together with the atoms to which they are connected, form a condensed ring of 3 to 7 members which is optionally substituted; where R¹ and R² are none H; and where R¹ and R² are none absent; each R³ is independently halogen, aliphatic C₁₋₆,aryl C₅₋₁₀,A saturated or partially unsaturated carbon thyroid ring, consisting of 3 to 8 members, 3 to 7 members, and 1 to 4 heteroatoms independently selected from nitrogen, oxygen or sulfur, O a five to six member heterocyclic ring, consisting of 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, each R-R, so, SOR, C (o), co8322; R-C (o) n (R) 8322;Each r83099 is independent of - R, halogen, or, sir, CN,-SO R -SOR -C (O) R -CO R -C (O) N (R)-NRC (O) R -NRC (O) N (R)-So8322; R-N (R) 832222;each R is independently hydrogen, aliphatic C₁₋₆,aryl C₅₋₁₀,a saturated 3-8-membered saturated or partially unsaturated carbocyclic ring, a 3- to 7-membered heterocyclic ring having 1-4 heteroatoms independently
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充