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As AHR activator 1,2-dihydro-4-hydroxy-2-oxo - quinoline-3-carboxylate anilide
专利权人:
イムナール アクティエボラーグ
发明人:
ラース ペッテション
申请号:
JP2013532745
公开号:
JP5676769B2
申请日:
2011.10.11
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The present invention relates to compounds which are 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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