To provide a dry-type hollow-fiber membrane module which has excellent blood compatibility and less releases a component therefrom, the hollow-fiber membranes which have been built into the module, and a process for producing the hollow-fiber membrane module. A hollow-fiber membrane module having built-in hollow-fiber membranes which comprise a hydrophobic polymer and a hydrophilic-group-containing polymer, characterized by satisfying the following items. (a) The hollow-fiber membranes have a water content of 10 wt% or less relative to the weight thereof (b) The hydrophobic polymer contains no nitrogen, the hydrophilic-group-containing polymer contains nitrogen, and the hollow-fiber membranes have a nitrogen content of 0.05-0.4 wt% (c) The content of the hydrophilic-group-containing polymer in the inner surface of each membrane is 20-45 wt% (d) The amount of 2.010-3 mol/L aqueous potassium permanganate solution for titration consumed by the substances dissolved in 10 mL of a final priming liquid is 0.2 mL or less per m2 of the membrane area.本發明之課題在於提供血液適合性優越、溶出物少之乾型之中空絲膜模組,與內藏於該模組之中空絲膜及中空絲膜模組之製造方法。本發明之解決手段為一種中空絲膜模組,其特徵為,內藏著含有疏水性高分子與含親水性基高分子之中空絲膜,並滿足以下項目。(a)相對於上述中空絲膜之自重的含水率為10重量%以下;(b)上述疏水性高分子不含氮,上述含親水性基高分子含有氮,上述中空絲膜之含氮率為0.05重量%以上且0.4重量%以下;(c)上述膜內表面之含親水性基高分子之含有率為20重量%以上且45重量%以下;(d)相對於灌注終流液10mL中之溶出物,用於滴定之2.0×10-3mol/L過錳酸鉀水溶液之消耗量係膜面積1m2為0.2mL以下。
