A tissue supporting device is disclosed, comprising: a generally cylindrical tissue supporting device body (300400500600) configured to support a bodily lumen a plurality of first through openings (330a430a 530a630a) in the tissue supporting device body (300 400500600), wherein the first openings (330a430a 530a630a) contain a first beneficial agent and a plurality of second through openings (330b430b530b 630b) in the tissue supporting device body (300400 500600), wherein the second openings (330b430b530b 630b) contain a second beneficial agent, characterized in that the second beneficial agent is different from the first beneficial agent.