抗ムスカリン剤およびPDE4阻害剤を含む組合せ剤

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专利权人:

アルミラル・ソシエダッド・アノニマ

发明人:

ジョルディ・グラス・エスカルド,ヘスス・リェナス・カルボ,ハミッシュ・ライダー,ピオ・オルビス・ディアス

申请号：

JP2007513835

公开号：

JP5133054B2

申请日:

2005.05.31

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

Combination (I) comprises a phosphodiesterase inhibitor 4 (PDE4) (A) and an antagonist of M3 muscarinic receptors (B) (3(R)-(2-hydroxy-2, 2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo [2.2.2] octane), in the form of a salt having an anion X (anion of a mono or polyvalent acid). An independent claim is also included for a method of treating a patient suffering from or susceptible to a respiratory disease or condition which responds to M3 antagonism comprising simultaneous, concurrent, separate or sequential administration of (I). - ACTIVITY : Antiasthmatic Respiratory-Gen. Antiinflammatory. - MECHANISM OF ACTION : Phosphodiesterase-4 inhibitor Muscarinic receptors antagonist Leukotriene-D4 antagonist Neurokinin-1- receptor antagonist Epidermal growth factor receptor kinase inhibitor Beta-2 agonist p38 Kinase inhibitor.

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中国工程科技知识中心

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