The present invention refers to pharmaceutical, dietary and/or nutraceuticalorosoluble and/or effervescentcompo-sitions for oral use containing at least a salt of S-adenosyl methionine(SAMe), combined with physiologically acceptableexcipi-ents and optionally additional active ingredients. In particular theinvention refers to compositions with high palatabilityformulat-ed in tablet, capsule or granules. The present invention also refersto the use of at least a salt of SAMe combined withphysiologi-cally acceptable excipients and optionally further activeingredients for treating, human or veterinarian, neuropsychiatric,osteoar-ticular or hepatic diseases.