結合CD33、NKG2D及CD16之多特異性結合蛋白及使用方法农业专利-农业专业知识服务系统

发明人:: CHANG, GREGORY P.,张　葛雷哥里　Ｐ,張　葛雷哥里　Ｐ,CHEUNG, ANN F.,张　莺娥,張　鶯娥,GRINBERG, ASYA,葛林柏格　埃斯雅,葛林柏格　埃斯雅,SETHI, DHRUV KAM,西斯　杜鲁夫　肯,西斯　杜魯夫　肯,HANEY, WILLIAM,哈尼　威廉,哈尼　威廉,PRINZ, BIANKA,普林斯　毕安卡,普林斯　畢安卡

摘要：: Multi-specific binding proteins that bind to and kill human cancer cells expressing CD33 (Siglec-3) are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of CD33 expressing cancer. The invention relates to multi-specific binding proteins that bind to human cancer cells expressing CD33, and exhibit high potency and maximum lysis of target cells compared to anti-CD33 monoclonal antibodies.本發明提供結合至且殺死表現CD33 (唾液酸結合免疫球蛋白樣凝集素-3 (Siglec-3))之人類癌細胞的多特異性結合蛋白，以及可用於治療表現CD33之癌症的醫藥組合物及治療方法。本發明係關於結合至表現CD33之人類癌細胞，且相較於抗CD33單株抗體展現對靶細胞之高效力及最大溶解的多特異性結合蛋白。