MFAP4 BINDING ANTIBODIES BLOCKING THE INTERACTION BETWEEN MFAP4 AND INTEGRIN RECEPTORS

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专利权人:

SYDDANSK UNIVERSITET

发明人:

SOERENSEN, GRITH LYKKE,SCHLOSSER, ANDERS,HOLMSKOV, UFFE

申请号：

EP14743707

公开号：

EP2948472A4

申请日:

2014.01.22

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Microfibrillar-associated protein 4 (MFAP4) binding antibodies are provided to prevent or to inhibit the proliferation of vascular smooth muscle cells and neointima formation in blood vessels. Furthermore, there are provided antibodies that effectively inhibit remodelling of vessels and prevent progression of arteriosclerosis as well as restenosis of vessels. The provided antibodies block the interaction between MF AP4 and integrin receptors.

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