A controller is operable to selectively supply gas to, and evacuate gas from,regions of ahyperbaric wound treatment chamber The controller operates to inflate apassage or rib ofthe device to provide that the device is made sufficiently rigid for insertinga limb therethrough, and inflate an inflatable cuff to create a seal against the limb Thecontroller alsooperates to evacuate ambient air trappe within the chamber, and optionallypartially evacuatethe passage or rib, after the seal is created by the inflatable cuff, and thenintroduce oxygeninto the chamber, and optionally inflate the passage or pb The cuff, wheninflated andcreating a seal against a limb, optionally Is at least partially within thechamber, and thetreatment gas is supplied to the chamber to maintain the seal of the cuffagainst the limb
