An ice machine prevents micro-organism growth by utilizing a clean-in-place process. The ice making process of the ice making machine is turned OFF, and then ozonated water, from an ozonated water generation system, is pumped into a distribution system, within the ice making machine so that the ozonated water is sprayed onto surfaces of the ice making machine which are susceptible to micro-organism growth and/or scale. Exposing the surfaces to ozonated water kills the micro-organisms and rinses the dead micro-organisms out of the ice making machine.