DU, YUGUANG,CHENG, GONG,JIA, PEIYUAN,SUN, MING,JIAO, SIMING,REN, LISHI,FENG, CUI
申请号：
CA3041417
公开号：
CA3041417A1
申请日:
2017.11.08
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Provided are a chitooligosaccharide of a specific structure, a preparation method therefor and use thereof. The reducing and non-reducing ends of all components of the chitooligosaccharide are glucosamine, and the degree of deacetylation is 50% - 80%. The chitooligosaccharide may be obtained by means of enzymatic hydrolysis of a chitosan substrate, and the enzyme used is capable of specifically recognizing and hydrolyzing glycosidic bonds formed from glucosamine and glucosamine, such that the reducing and non-reducing ends of all components of the chitooligosaccharide, which are obtained by hydrolysis, are both glucosamine. Compared with chitooligosaccharides of common structures, the chitooligosaccharide of the specific structure has a higher inhibitory activity on liver cancer cells, and can be applied to the fields of prevention and adjuvant therapy of liver cancer and the like.
