Maria Jose Guerrero Martinez,Laureano Simon Buela,Marcel Ferrer-Alcon,Antonio Martinez Martinez,Jose Javier Meana,Luis Felipe Callado,Leyre Uriguen
申请号：
US13059938
公开号：
US09267151B2
申请日:
2009.08.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.
