МАКАФФЕР Иан Камерон Гарднер (GB),ТАСКО Питер Эрнст (GB),СВИФТ Грэхем Джон (GB),ЖАНФРАНЧЕСКО Сушила (GB)
申请号：
RU2012109599/15
公开号：
RU2012109599A
申请日:
2010.08.16
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A composition for powder inhaler (DPI), characterized in that 90 wt.% Or more of the composition is beclomethasone solvate and up to 10 wt.% Of the composition is a carrier or excipient, and where beclomethasone solvate is obtained by forming a suspension (i) of droplets containing beclomethasone, dissolved in a solvent, in (ii) water or C-carbohydrate, as a non-solvent for beclomethasone, and by treating these droplets with ultrasound to form crystallized beclomethasone particles. 2. A composition for a powder inhaler according to claim 1, characterized in that said C-hydrocarbon is non-cyclic, linear or branched. A composition for a powder inhaler according to claim 2, characterized in that said C-carbohydrate is heptane. A composition for a powder inhaler according to claim 3, characterized in that said heptane is n-heptane. A powder inhaler composition according to any one of claims 1 to 5, comprising beclomethasone solvate particles with a diameter of 0.5-10 microns. 6. A composition for a powder inhaler according to claim 5, characterized in that the particle size distribution corresponds to the following range of values: X =>； 0.1 μm, X = <；5 μm and X = <；10 μm. 7. A composition for a powder inhaler according to claim 6, characterized in that the particle size distribution corresponds to the following range of values: X =>； 0.5 μm, X = <；3 μm and X = <；7 μm. A composition for a powder inhaler according to claim 7, characterized in that the particle size distribution corresponds to the following range of values: X =>； 0.5 μm, X = <；3 μm and X = <；5 μm. A composition for a powder inhaler according to claim 1, comprising beclomethasone particles that have morphology, homogen1. Композиция для порошкового ингалятора (DPI), отличающаяся тем, что 90 мас.% или более композиции составляет сольват беклометазона и до 10 мас.% композиции составляет носитель или эксципиент, и где сольват беклометазона получен при формировании суспензии (i) капелек, со
