Joseph John Binder,Helen Kim Cho,Michael Robert Dermyer,Karin Ute Jooss,Brian Gregory Pierce,Joyce Tsi Tan,Van To Tsai
申请号:
US13875162
公开号:
US09066898B2
申请日:
2013.05.01
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.