腎外髓質鉀通道抑制劑农业专利-农业学术服务平台

发明人:: WALSH, SHAWN,华许　夏恩,華許　夏恩,PASTERNAK, ALEXANDER,派斯特纳克　亚力山德,派斯特納克　亞力山德,FRIE, JESSICA,芙瑞　洁西卡,芙瑞　潔西卡,PIO, BARBARA,比欧　芭芭拉,比歐　芭芭拉,SHAHRIPOUR, AURASH,沙荷波尔　奥拉旭,沙荷波爾　奧拉旭,SHI, ZHI-CAI,石志材,TANG, HAIFENG,唐海方,唐,华许夏恩,華許夏恩,派斯特纳克亚力山德,派斯特納克亞力山德,芙瑞洁西卡,芙瑞潔西卡,比欧芭芭拉,比歐芭芭拉,沙荷波尔奥拉旭,沙荷波爾奧拉旭

摘要：: This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.本發明係關於具有結構式I之化合物：及其醫藥學上可接受之鹽，其為腎外髓質鉀(Renal Outer Medullary Potassium,ROMK)通道(Kir1.1)之抑制劑。該等式I化合物適用作利尿劑及鈉利尿劑，且因此適用於治療及預防由過量鹽及水滯留所致之病症，包括心血管疾病，諸如高血壓以及慢性及急性心臟衰竭。