Provided herein is technology relating to compositions containing bioactive non-methylene interrupted fatty acids (NMIFAs) in combination with short chain fatty acids, medium chain fatty acids, ketone bodies and/or endocannabinoids and endocannabinoid-related mediators, and particularly, but not exclusively, to compositions and methods related to the production and use of non-methylene interrupted fatty acids such as sciadonic acids, juniperonic acid, pinoleic acid and dihomopinoleic acid in combination with short chain fatty acids, medium chain fatty acids and/or endocannabinoids and endocannabinoid-related mediators.
