2-aminoquinolines en tant qu'antagonistes du récepteur 5-HT5A, leur préparation et les compositions pharmaceutiques qui les contiennent

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

申请号：

EP09718172.1

公开号：

EP2262774B1

申请日:

2009.02.25

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention is concerned with 2-aminoquinoline derivatives of formula I wherein Z, R1, and Ar1 are as defined herein, pharmaceutical compositions containing them, methods for their manufacture. The compounds are 5-HT5A receptor antagonists and are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

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中国工程科技知识中心

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