The present embodiments provide methods, compounds, and compositions useful for inhibiting PNPLA3 expression, which may be useful for treating, preventing, or ameliorating a disease associated with PNPLA3.本發明實施方式提供了可用於抑制PNPLA3表現之方法、化合物、和組成物,該等方法、化合物、和組成物可用於治療、預防、或緩解與PNPLA3相關聯之疾病。