KELLIHER, ADAM A,MORRISON, ANGUS A,KNOWLES, PHIL P,.凱立爾,.莫裡森,.諾爾斯
申请号：
HK12106556.9
公开号：
HK1165728B
申请日:
2012.07.04
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I),or a pharmaceutically acceptable salt, or solvate thereof, wherein- -Alk- is -CH(OR<；sub>；2<；/sub>；)-[trans]CH=CH-[cis]CH=CH-CH<；sub>；2<；/sub>；-[cis]CH=CH-C<；sub>；3<；/sub>；H<；sub>；6<；/sub>；-,-(CH<；sub>；2<；/sub>；)<；sub>；3<；/sub>；-CH(OR<；sub>；2<；/sub>；)-[trans]CH=CH-[cis]CH=CH-CH<；sub>；2<；/sub>；-[cis]CH=CH-, -(CH<；sub>；2<；/sub>；)<；sub>；3<；/sub>；-[cis]CH=CH-CH<；sub>；2<；/sub>；-[cis]CH=CH-[trans]CH=CH-CH(OR<；sub>；2<；/sub>；)- or -CH<；sub>；2<；/sub>；-[cis]CH=CH-CH<；sub>；2<；/sub>；-[cis]CH=CH-[trans]CH=CH-CH(OR<；sub>；2<；/sub>；)-；- R<；sub>；1<；/sub>；is a hydrogen atom； orR<；sub>；1<；/sub>；is a C<；sub>；1<；/sub>；-C<；sub>；6<；/sub>；alkyl, C<；sub>；2<；/sub>；-C<；sub>；6<；/sub>；alkenyl, C<；sub>；2<；/sub>；-C<；sub>；6<；/sub>；alkynyl, C<；sub>；6<；/sub>；-C<；sub>；10<；/sub>；aryl, 5- to 10-membered heteroaryl, C<；sub>；3<；/sub>；-C<；sub>；7<；/sub>；carbocyclyl or 5- to 10-membered heterocyclyl group； or R<；sub>；1<；/sub>；is a group of formula -CH<；sub>；2<；/sub>；-CH(OR<；sub>；3<；/sub>；)-CH<；sub>；2<；/sub>；-(OR<；sub>；4<；/sub>；), wherein R<；sub>；3<；/sub>；and R<；sub>；4<；/sub>；are each independently hydrogen atoms or -(C=O)-R<；sub>；6<；/sub>；, wherein R<；sub>；6<；/sub>；is an aliphatic group having from 3 to 29 carbon atoms； orR<；sub>；1<；/sub>；is a group of formula -(CH<；sub>；2<；/sub>；OCH<；sub>；2<；/sub>；)<；sub>；m<；/sub>；OH, wherein m is an integer of from 1 to 200；- R<；sub>；2<；/sub>；is a hydrogen atom； orR<；sub>；2<；/sub>；is a group -(C=O)-R<；sub>；5<；/sub>；, wherein R<；sub>；5<；/sub>；is a C<；sub>；1<；/sub>；-C<；sub>；6<；/sub>；alkyl, C<；sub>；2<；/su
